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Journal Article 8

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Gut microbiota 2

Allergic diseases 1

Atypical clinical characteristics 1

Bayesian bootstrap 1

Big Three Gorges area 1

COVID-19 1

China Railway Express 1

Gut barrier function 1

Hajj 1

Hay fever 1

Intestinal barrier dysfunction 1

Latin hypercube sampling 1

Metabolome 1

Non-alcoholic steatohepatitis 1

Pien Tze Huang 1

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classical swine fever virus 1

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Multi-Omics Analysis Provides Insight into the Possible Molecular Mechanism of Hay Fever Based on Gut Article

Pei Han, Li-Sha Li, Zi-Xi Wang, Lin Xi, Hang Yu, Lin Cong, Zheng-Wei Zhang, Jie Fu, Ran Peng, Li-Bin Pan, Shu-Rong Ma, Xue-Yan Wang, Hong-Tian Wang, Xiang-Dong Wang, Yan Wang, Jin-Lyu Sun, Jian-Dong Jiang

Engineering 2022, Volume 15, Issue 8,   Pages 115-125 doi: 10.1016/j.eng.2021.03.013

Abstract: inhibiting the expression of claudin proteins and affecting the mucus layer, which further results in hayfever.

Keywords： Metabolome     Gut microbiota     Hay fever     Allergic diseases     Intestinal barrier dysfunction    

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Yellow fever and Hajj: with all eyes on Zika, a familiar flavivirus remains a threat

Qanta A. Ahmed,Ziad A. Memish

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 527-530 doi: 10.1007/s11684-016-0487-2

Abstract: With yellow fever reported for the first time in China following the infection of expatriate Chineseworkers in Angola and a full blown outbreak underway in wider West Africa, the prospect of yellow feverWith global focus trained on Zika, the rising threat of yellow fever cannot be overlooked.

Keywords： yellow fever     mass gathering     Saudi Arabia     Hajj     Zika virus    

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Connecting the Belt and Road through sea-rail collaboration

Chenhao ZHOU, Haobin LI, Wencheng WANG, Loo Hay LEE, Ek Peng CHEW

Frontiers of Engineering Management 2017, Volume 4, Issue 3,   Pages 315-324 doi: 10.15302/J-FEM-2017031

Abstract: As part of China’s “the Belt and Road” strategy, China Railway Express provides alternative shipping routes and transportation modes from Asia to Europe and creates new opportunities for intermodal transportation in the shipping industry. A time–distance-based cost (time cost) function was proposed to compare China Railway Express with traditional transportation modes. Time cost was related to different types of cargoes, which exhibit distinct sensitivity to time. Using the proposed cost function as basis, we identified the cost indifference area where total costs are equal. Further analysis was performed for selecting the transportation mode and supply area for a specific cargo. This study provides various parties, such as business owners, the government, and the shipping industry, with many valuable insights.

Keywords： China Railway Express     the Belt and Road     shipping industry     combined transportation    

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Efficient purification of cell culture-derived classical swine fever virus by ultrafiltration and size-exclusion

Ruining WANG,Yubao ZHI,Junqing GUO,Qingmei LI,Li WANG,Jifei YANG,Qianyue JIN,Yinbiao WANG,Yanyan YANG,Guangxu XING,Songlin QIAO,Mengmeng ZHAO,Ruiguang DENG,Gaiping ZHANG

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 3,   Pages 230-236 doi: 10.15302/J-FASE-2015071

Abstract: Large-scale production of cell culture-based classical swine fever virus (CSFV) vaccine is hampered by

Keywords： classical swine fever virus     virus purification     tangential-flow filtration     size-exclusion chromatography    

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A case study on sample average approximation method for stochastic supply chain network design problem

Yuan WANG, Ruyan SHOU, Loo Hay LEE, Ek Peng CHEW

Frontiers of Engineering Management 2017, Volume 4, Issue 3,   Pages 338-347 doi: 10.15302/J-FEM-2017032

Abstract: This study aims to solve a typical long-term strategic decision problem on supply chain network design with consideration to uncertain demands. Existing methods for these problems are either deterministic or limited in scale. We analyze the impact of uncertainty on demand based on actual large data from industrial companies. Deterministic equivalent model with nonanticipativity constraints, branch-and-fix coordination, sample average approximation (SAA) with Bayesian bootstrap, and Latin hypercube sampling were adopted to analyze stochastic demands. A computational study of supply chain network with front-ends in Europe and back-ends in Asia is presented to highlight the importance of stochastic factors in these problems and the efficiency of our proposed solution approach.

Keywords： supply chain network     stochastic demand     sampling average approximation     Bayesian bootstrap     Latin hypercube sampling    

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Pien Tze Huang Protects Against Non-Alcoholic Steatohepatitis by Modulating the Gut Microbiota and Metabolites in Mice

Xianyi Zeng,Xiang Zhang,Hao Su,Hongyan Gou,Harry Cheuk-Hay Lau,Xiaoxu Hu,Ziheng Huang,Yan Li,Jun Yu,

Engineering doi: 10.1016/j.eng.2022.10.010

Abstract: Non-alcoholic steatohepatitis (NASH) is a severe form of non-alcoholic fatty liver disease without effective treatment. The traditional Chinese medicine formulation Pien Tze Huang (PTH) can suppress inflammatory diseases. Here, we evaluate the effects of PTH on the evolution of NASH and its underlying mechanisms. We found that PTH prevented the development of steatohepatitis induced by various dietary models, including a high-fat high-cholesterol (HFHC) diet, choline-deficient high-fat diet (CD-HFD), and methionine- and choline-deficient (MCD) diet, along with significant suppression of liver injury, hepatic triglyceride, and lipid peroxidation. Moreover, ten days of PTH treatment after the onset of NASH significantly ameliorated MCD diet-induced steatosis and liver injury in mice. Through the metagenomic sequencing of stool samples, we found that PTH administration restored the gut microbiota with enrichment of probiotics including Lactobacillus acidophilus (L. acidophilus), Lactobacillus plantarum, Lactococcus lactis, and Bacillus subtilis. The enriched L. acidophilus prevented MCD diet-induced steatohepatitis. In addition, PTH restored the gut barrier function in mice with steatohepatitis, as evidenced by reduced intestinal permeability, decreased serum lipopolysaccharides (LPS) level, and increased epithelial tight-junction protein E-cadherin expression. Our metabolomic analysis via liquid chromatography-mass spectrometry profiling identified the alteration in the metabolism of bile acids in the portal vein of PTH-treated mice. We further confirmed that an intact gut microbiota is necessary for PTH to exhibit anti-steatohepatitis effects. In conclusion, PTH protects against steatohepatitis development by modulating the gut microbiota and metabolites. PTH is a potential promising prophylactic and therapeutic option for patients with NASH.

Keywords： Pien Tze Huang     Non-alcoholic steatohepatitis     Gut barrier function     Gut microbiota    

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Characteristics and Outcomes of Severe or Critical COVID-19 Patients Presenting No Respiratory Symptoms or Fever Article

Juanjuan Xu, Zhengrong Yin, Yu Liu, Sufei Wang, Limin Duan, Yi An, Jinshuo Fan, Tingting Liao, Yang Jin, Jianguo Chen

Engineering 2021, Volume 7, Issue 10,   Pages 1454-1460 doi: 10.1016/j.eng.2020.09.009

Abstract: radiological profiles, treatments, and outcomes of atypical COVID-19 patients without respiratory symptoms or feverfrom the electronic medical records of severe or critical patients without respiratory symptoms or feverOf the severe or critical patients, ten (1.1%) presented without respiratory symptoms or fever at admissionIn summary, some severe or critical COVID-19 patients were found to have no respiratory symptoms or feverscreen out those with atypical infections, even if the contacts present without respiratory symptoms or fever

Keywords： SARS-CoV-2     COVID-19     Atypical clinical characteristics    

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Relationship between the incidence of HFRS and changes of land-use in Big Three Gorges area of Chongqing Municipality, China

Lei YAN MD, MPH, PhD, Shi-Wen WANG MD, PhD, Yu-Huan REN PhD, Jing ZHANG MD, Pei-Long LI MD, Wei-Zhong YANG MD, PhD, Xin-Li WANG MD, De-Qiang MAO MD,

Frontiers of Medicine 2010, Volume 4, Issue 2,   Pages 199-203 doi: 10.1007/s11684-010-0042-5

Abstract: intended to find out the relationships between the environmental changes and the incidence of hemorrhagic fever

Keywords： hemorrhagic fever with renal syndrome     land-use     Big Three Gorges area    

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Title Author Date Type Operation

Multi-Omics Analysis Provides Insight into the Possible Molecular Mechanism of Hay Fever Based on Gut

Pei Han, Li-Sha Li, Zi-Xi Wang, Lin Xi, Hang Yu, Lin Cong, Zheng-Wei Zhang, Jie Fu, Ran Peng, Li-Bin Pan, Shu-Rong Ma, Xue-Yan Wang, Hong-Tian Wang, Xiang-Dong Wang, Yan Wang, Jin-Lyu Sun, Jian-Dong Jiang

Journal Article

Yellow fever and Hajj: with all eyes on Zika, a familiar flavivirus remains a threat

Qanta A. Ahmed,Ziad A. Memish

Journal Article

Connecting the Belt and Road through sea-rail collaboration

Chenhao ZHOU, Haobin LI, Wencheng WANG, Loo Hay LEE, Ek Peng CHEW

Journal Article

Efficient purification of cell culture-derived classical swine fever virus by ultrafiltration and size-exclusion

Ruining WANG,Yubao ZHI,Junqing GUO,Qingmei LI,Li WANG,Jifei YANG,Qianyue JIN,Yinbiao WANG,Yanyan YANG,Guangxu XING,Songlin QIAO,Mengmeng ZHAO,Ruiguang DENG,Gaiping ZHANG

Journal Article

A case study on sample average approximation method for stochastic supply chain network design problem

Yuan WANG, Ruyan SHOU, Loo Hay LEE, Ek Peng CHEW

Journal Article

Pien Tze Huang Protects Against Non-Alcoholic Steatohepatitis by Modulating the Gut Microbiota and Metabolites in Mice

Xianyi Zeng,Xiang Zhang,Hao Su,Hongyan Gou,Harry Cheuk-Hay Lau,Xiaoxu Hu,Ziheng Huang,Yan Li,Jun Yu,

Journal Article

Characteristics and Outcomes of Severe or Critical COVID-19 Patients Presenting No Respiratory Symptoms or Fever

Juanjuan Xu, Zhengrong Yin, Yu Liu, Sufei Wang, Limin Duan, Yi An, Jinshuo Fan, Tingting Liao, Yang Jin, Jianguo Chen

Journal Article

Relationship between the incidence of HFRS and changes of land-use in Big Three Gorges area of Chongqing Municipality, China

Lei YAN MD, MPH, PhD, Shi-Wen WANG MD, PhD, Yu-Huan REN PhD, Jing ZHANG MD, Pei-Long LI MD, Wei-Zhong YANG MD, PhD, Xin-Li WANG MD, De-Qiang MAO MD,

Journal Article